• 

  Time-encoded electrical detection of trace RNA biomarker by integrating programmable molecular amplifier on chip

  One of the serious challenges facing modern point-of-care (PoC) molecular diagnostic platforms relate to reliable detection of low concentration biomarkers such as nucleic acids or proteins in biological samples. Non-specific analyte-receptor (...)

  
  
• 

  Pattern formation by turbulent cascades

  Fully developed turbulence is a universal and scale-invariant chaotic state characterized by an energy cascade from large to small scales at which the cascade is eventually arrested by dissipation1,2,3,4,5,6. Here we show how to harness these (...)

  
  
• 

  Odd elasticity and topological waves in active surfaces

  Odd elasticity describes active elastic systems whose stress-strain relationship is not compatible with a potential energy. As the requirement of energy conservation is lifted from linear elasticity, new antisymmetric (odd) components appear in (...)

  
  
• 

  Interplay between Markovianity and progressive quenching

  Progressive quenching (PQ) is a process in which we sequentially fix a system’s degrees of freedom, which would otherwise evolve according to their stochastic dynamics. Previous studies have discovered what we refer to as the hidden martingale (...)

  
  
• 

  Functional analysis of single enzymes combining programmable molecular circuits with droplet-based microfluidics

  The analysis of proteins at the single-molecule level reveals heterogeneous behaviours that are masked in ensemble-averaged techniques. The digital quantification of enzymes traditionally involves the observation and counting of single (...)

  
  
• 

  Coupling Exponential to Linear Amplification for Endpoint Quantitative Analysis

  Exponential DNA amplification techniques are fundamental in ultrasensitive molecular diagnostics. These systems offer a wide dynamic range, but the quantification requires real-time monitoring of the amplification reaction. Linear amplification (...)

  
  
• 

  In Vitro Enzyme Self-Selection Using Molecular Programs

  Directed evolution provides a powerful route for in vitro enzyme engineering. State-of-the-art techniques functionally screen up to millions of enzyme variants using high throughput microfluidic sorters, whose operation remains technically (...)

  
  
• 

  Dynamical order and many-body correlations in zebrafish show that three is a crowd

  Zebrafish constitute a convenient laboratory–based biological system for studying collective behavior. It is possible to interpret a group of zebrafish as a system of interacting agents and to apply methods developed for the analysis of systems (...)

  
  
• 

  Odd elasticity and topological waves in active surfaces

  Odd elasticity describes active elastic systems whose stress-strain relationship is not compatible with a potential energy. As the requirement of energy conservation is lifted from linear elasticity, new antisymmetric (odd) components appear in (...)

  
  
• 

  Noise-induced collective actuation in active solids

  Collective actuation describes the spontaneous synchronized oscillations taking place in active solids when the elasto-active feedback, which generically couples the reorientation of the active forces and the elastic stress, is large enough. In (...)

  
  

Top