Accurate gene consensus at low nanopore coverage

Nanopore technologies allow high-throughput sequencing of long strands of DNA at the cost of a relatively large error rate. This limits its use in the reading of amplicon libraries in which there are only a few mutations per variant and therefore they are easily confused with the sequencing noise. Consensus calling strategies reduce the error but sacrifice part of the throughput on reading typically 30 to 100 times each member of the library.


Top



See also...

Universal motifs and the diversity of autocatalytic systems

Autocatalysis is essential for the origin of life and chemical evolution. However, the lack of a unified framework so far prevents a systematic (...) 

> More...

Adaptive strategies in Kelly’s horse races model

We formulate an adaptive version of Kelly’s horse model in which the gambler learns from past race results using Bayesian inference. We (...) 

> More...