Programmable matter

Programmable matters encompasses apparently different research fields, from molecular programming to swarm robotics, which share a common language. Taking advantage of DNA nanotechnologies and molecular programming, it is possible to rationally build artificial DNA/enzyme-based reaction networks that emulate cellular functionalities. Taking advantage of a joined morpho-physical and logical computing, populations of robots collectively learn the realization of tasks, they would not achieve otherwise.

Replicating systems

Survival of self-replicating molecules under transient compartmentalization with natural selection, G. Laurent, L. Peliti and D. Lacoste, Life 9,78 (2019).
The generality of transient compartmentalization and its associated error threshold, A. Blokhuis, P. Nghe, L. Peliti and D. Lacoste, J. Theor. Bio, 487, 110110 (2020).
Selection strategies for randomly distributed replicators, A. S. Zadorin and Y. Rondelez, PRE 99, 062416 (2019).
Self-replicating colloidal clusters, Z. Zeravcic, M. P. Brenner, PNAS 111, 5 (2014).
Mutation at Expanding Front of Self-Replicating Colloidal Clusters, H. Tanaka, Z. Zeravcic and M. P. Brenner, PRL 117, 23, (2016)

Molecular circuits

Microscopic agents programmed by DNA circuits, G. Gines, A. Zadorin et al., Nature Nanotech 12, 351–359 (2017).
High-resolution mapping of bifurcations in nonlinear biochemical circuits, A. Genot, A. Baccouche, R. Sieskind, et al., Nature Chem 8, 760–767 (2016).
DNA Computing and Molecular Programming, Y. Rondelez and D. Woods, 22nd International Conference, DNA 22, Munich, Germany, September 4-8, 2016.

Directed evolution and diagnostics

The PEN CSR, using external molecular programs to control directed evolution of enzymes, A. Dramé-Maigné, R. Espada, G. MacCallum and Y. Rondelez, Enzyme Engineering XXV, University of Illinois at Urbana-Champaign, ECI Symposium Series, (2019).
Accurate detection of single nucleotide polymorphisms using nanopore sequencing, R. Espada, N. Zarevski, A. Drame-Maigne and Y. Rondelez, bioRxiv (2020).
Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies, G. Gines, R. Menezes, W. Xiao, Y. Rondelez and V. Taly, Molecular Aspects of Medicine 72, 100832 (2020).

Principles of self-assembly

Evolutionary optimization of self-assembly in a swarm of bio-micro-robots, N. Aubert-Kato, C. Fosseprez, G. Gines et al., Proceedings of the Genetic and Evolutionary Computation Conference (GECCO ’17). Association for Computing Machinery, New York, NY, USA, 59–66, (2017).
Size limits of self-assembled structures, Z. Zeravcic, V. N. Manoharan, M. P. Brenner, PNAS 111, 45 (2014)
Colloquium: Toward living matter with colloidal particles, Z. Zeravcic, V. N. Manoharan and M. P. Brenner, Rev. Mod. Phys. 89, 3 (2017).

Yannick RONDELEZ | webpage | Google Scholar |
Zorana ZERAVCIC | webpage | Google Scholar |
Guillaume GINES | webpage | Google Scholar |
David LACOSTE | webpage | Google Scholar |
Olivier DAUCHOT | webpage | Google Scholar |